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Triamcinolone benetonide

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Triamcinolone
Systematic (IUPAC) name
(11β,16α)-9-fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
Clinical data
Trade names Kenalog Nasacort
AHFS/Drugs.com monograph
Pregnancy cat. A (AU) C (US)
Legal status POM (UK) -only (US)
Routes Oral, topical, IM, intra-articular, intrasynovial
Pharmacokinetic data
Protein binding 68%
Metabolism Hepatic
Half-life 88 minutes
Excretion Fecal and renal
Identifiers
CAS number 124-94-7 YesY
ATC code A01AC01 C05AA12, D07AB09, H02AB08, R01AD11, R03BA06, S01BA05
PubChem CID 31307
IUPHAR ligand 2870
DrugBank DB00620
ChemSpider 29046 YesY
UNII 1ZK20VI6TY YesY
KEGG D00385 YesY
ChEBI CHEBI:9667 N
ChEMBL CHEMBL1451 YesY
Synonyms
Chemical data
Formula C21H27FO6 
Mol. mass 394.434 g/mol
 N (what is this?)  (verify)

Triamcinolone is a long-acting synthetic corticosteroid given orally, by injection, by inhalation, or as a topical ointment or cream.

Uses

Triamcinolone is used to treat several different medical conditions, such as eczema, psoriasis, arthritis, allergies, ulcerative colitis, lupus, sympathetic ophthalmia, temporal arteritis, uveitis, ocular inflammation, Urushiol-induced contact dermatitis, visualization during vitrectomy and the prevention of asthma attacks. It will not treat an asthma attack once it has already begun. It has also been used off-label for macular degeneration.

Prior to 2007 it was manufactured under the name Azmacort as a corticosteroid inhaler for asthma long-term care. The patent holder, Sanofi, sold it under the brand name Nasacort.

In 2010, TEVA and Perrigo launched the first generic inhalable triamcinolone.

Triamcinolone is used to alleviate infection-induced eczema in fungal skin infections in the combination drug of econazole/triamcinolone.

Triamcinolone acetonide is one of the ingredients of Ledermix - an endodontic (tooth's root canal) lotion used between sessions.

Forms

Different triamcinolone derivatives are available, including acetonide, benetonide, furetonide, hexacetonide and diacetate.

Triamcinolone acetonide is a more potent type of triamcinolone, being about eight times as effective as prednisone.

Side effects

Side effects of triamcinolone include sore throat, nosebleeds, increased coughing, headache, and runny nose.[citation needed] White patches in the throat or nose indicate a serious side effect. Symptoms of an allergic reaction include rash, itch, swelling, severe dizziness, trouble breathing. An additional side effect for women is a prolonged menstrual cycle.

Trade names

Trade names for triamcinolone include Aristocort (Sandoz, now Novartis), Kenacort (Bristol-Myers Squibb), Kenalog (Bristol-Myers Squibb), Tricort (Cadila), Triaderm (Schering-Plough), Azmacort (KOS), Trilone, Volon A, Tristoject, Tricortone and Ratio-Triacomb.

See also

References

Aristocort (triamcinolone) topical cream
Kenalog (triamcinolone) IM injection
  1. Triamcinolone - Drugs.com
  2. Triamcinolone Inhalation - Drugs.com
  3. Alcon Receives FDA Approval of Triesence Injectable Triamcinolone Suspension for Use in Eye Surgery - Drugs.com
  4. Age-Related Macular Degeneration (AMD) Treatment
  5. Perrigo Announces Launch Of Generic Version Of Nasacort AQ - CBS Detroit
  6. "Drugs and Treatments - Nasacort AQ Nasl - Patient Handout". WebMD. Retrieved 2008-03-24. 

External links

  • Triamcinolone Topical | MedlinePlus
  • Triamcinolone (Topical Application Route) | MayoClinic

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