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PNU-22394

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PNU-22394
Systematic (IUPAC) name
6-Methyl-1,2,3,4,5,6-hexahydro-azepino[4,5-b]indole
Clinical data
Legal status ?
Identifiers
CAS number 15923-78-1 YesY
ATC code ?
PubChem CID 27559
ChEMBL CHEMBL6557 N
Chemical data
Formula C13H16N2 
Mol. mass 200.279 g/mol
 N (what is this?)  (verify)

PNU-22394 is a drug which acts as an agonist at serotonin 5-HT2receptors, with strongest binding affinity for 5-HT2A and 5-HT2C and slightly weaker at 5-HT2B, although it is only a full agonist at 5-HT2C, but partial agonist at 5-HT2A and 5-HT2B. It has anorectic effects in both animal studies and human trials, although it has never been developed for medical use.

See also

References

  1. McCall RB, Franklin SR, Hyslop DK, Knauer CS, Chio CL, Haber CL, Fitzgerald LW (2001). "PNU-22394, a 5-HT2C receptor agonist, reduced feeding in rodents and produces weight loss in humans". Soc Neurosci Abstr 27. Presentation 309.2. 
  2. Garfield AS, Heisler LK (2009). "Pharmacological targeting of the serotonergic system for the treatment of obesity". The Journal of Physiology 587 (1): 49–60. doi:10.1113/jphysiol.2008.164152. PMC 2670022. PMID 19029184. 

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