HRC (gene)

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Histidine rich calcium binding protein
Symbols HRC; MGC133236
External IDs OMIM: 142705 MGI: 96226 HomoloGene: 1622 GeneCards: HRC Gene
Species Human Mouse
Entrez 3270 15464
Ensembl ENSG00000130528 ENSMUSG00000038239
UniProt P23327 E9Q399
RefSeq (mRNA) NM_002152 NM_010473
RefSeq (protein) NP_002143 NP_034603
Location (UCSC) Chr 19:
49.65 – 49.66 Mb
Chr 7:
45.34 – 45.34 Mb
PubMed search [1] [2]

Sarcoplasmic reticulum histidine-rich calcium-binding protein is a protein that in humans is encoded by the HRC gene.

Histidine-rich calcium-binding protein is a luminal sarcoplasmic reticulum protein of 165 kD identified by its ability to bind low-density lipoprotein with high affinity


  1. Hofmann SL, Topham M, Hsieh CL, Francke U (Jul 1991). "cDNA and genomic cloning of HRC, a human sarcoplasmic reticulum protein, and localization of the gene to human chromosome 19 and mouse chromosome 7". Genomics 9 (4): 656–69. doi:10.1016/0888-7543(91)90359-M. PMID 2037293.  Cite uses deprecated parameters (help)
  2. ^ "Entrez Gene: HRC histidine rich calcium binding protein". 

Further reading

  • Anderson NL, Anderson NG (2003). "The human plasma proteome: history, character, and diagnostic prospects.". Mol. Cell Proteomics 1 (11): 845–67. doi:10.1074/mcp.R200007-MCP200. PMID 12488461. 
  • Hofmann SL, Brown MS, Lee E, et al. (1989). "Purification of a sarcoplasmic reticulum protein that binds Ca2+ and plasma lipoproteins.". J. Biol. Chem. 264 (14): 8260–70. PMID 2498310. 
  • Ridgeway AG, Petropoulos H, Siu A, et al. (1999). "Cloning, tissue distribution, subcellular localization and overexpression of murine histidine-rich Ca2+ binding protein.". FEBS Lett. 456 (3): 399–402. doi:10.1016/S0014-5793(99)00993-X. PMID 10462052. 
  • Lee HG, Kang H, Kim DH, Park WJ (2001). "Interaction of HRC (histidine-rich Ca(2+)-binding protein) and triadin in the lumen of sarcoplasmic reticulum.". J. Biol. Chem. 276 (43): 39533–8. doi:10.1074/jbc.M010664200. PMID 11504710. 
  • Sacchetto R, Damiani E, Turcato F, et al. (2002). "Ca(2+)-dependent interaction of triadin with histidine-rich Ca(2+)-binding protein carboxyl-terminal region.". Biochem. Biophys. Res. Commun. 289 (5): 1125–34. doi:10.1006/bbrc.2001.6126. PMID 11741309. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Kim E, Shin DW, Hong CS, et al. (2003). "Increased Ca2+ storage capacity in the sarcoplasmic reticulum by overexpression of HRC (histidine-rich Ca2+ binding protein).". Biochem. Biophys. Res. Commun. 300 (1): 192–6. doi:10.1016/S0006-291X(02)02829-2. PMID 12480542. 
  • Adkins JN, Varnum SM, Auberry KJ, et al. (2003). "Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry.". Mol. Cell Proteomics 1 (12): 947–55. doi:10.1074/mcp.M200066-MCP200. PMID 12543931. 
  • Anderson JP, Dodou E, Heidt AB, et al. (2004). "HRC is a direct transcriptional target of MEF2 during cardiac, skeletal, and arterial smooth muscle development in vivo.". Mol. Cell. Biol. 24 (9): 3757–68. doi:10.1128/MCB.24.9.3757-3768.2004. PMC 387749. PMID 15082771. 
  • Fan GC, Gregory KN, Zhao W, et al. (2004). "Regulation of myocardial function by histidine-rich, calcium-binding protein.". Am. J. Physiol. Heart Circ. Physiol. 287 (4): H1705–11. doi:10.1152/ajpheart.01211.2003. PMID 15191886. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
  • Arvanitis DA, Vafiadaki E, Fan GC, et al. (2007). "Histidine-rich Ca-binding protein interacts with sarcoplasmic reticulum Ca-ATPase.". Am. J. Physiol. Heart Circ. Physiol. 293 (3): H1581–9. doi:10.1152/ajpheart.00278.2007. PMID 17526652. 

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