In 2006, Lettieri signed a contract with SV Darmstadt 98, he was there until the second half of the 2006/2007 season when Wacker Burghausen appointed him as their manager, but in July he was sacked following the club's relegation. 6 months later he was appointed manager of Regionalliga Süd team SpVgg Weiden.
On the 9th February 2010, Gino Lettieri joined SV Wehen Wiesbaden of the 3rd Liga. His first 3 matches in charge were all losses, but they managed to avoid relegation by 8 points. After a good start to the season, Lettieri signed a new contract keeping him at the club until 30 June 2013 but on 15 February 2012 with the club dangerously hanging round the relegation zone, SV Wehen sacked him, and replaced him with Peter Vollmann the next day.
Gino Lettieri (German) Weltfussball.de, accessed: 10 December 2011
Gino Lettieri, neuer Trainer beim Drittligisten SV Wehen fussball.de